Pain and Rheumatoid Arthritis
HT-6184: An investigational Approach to Treating Rheumatoid Arthritis
Evelyn’s* Day
SAMPLE DAILY EXPERIENCES WITH PAIN AND RHEUMATOID ARTHRITISChronic pain profoundly affects Evelyn’s quality of life. Her persistent, often debilitating pain makes even simple tasks, like getting out of bed or preparing a meal, almost impossible. Her constant discomfort usually leads to fatigue, as her body expends extra energy to cope. Pain frequently disrupts her sleep, leading to a vicious cycle of exhaustion and heightened pain sensitivity.Emotionally, Evelyn’s chronic pain is isolating. She feels misunderstood by those around her, who can’t see her pain or fully grasp its impact. Evelyn often deals with frustration, anxiety, and depression.
Managing her pain requires navigating a complex web of medical treatments, therapies, and medications, which offer limited relief. The unpredictability of her flare-ups adds another layer of difficulty, making it hard to maintain a consistent routine.
How would Evelyn’s life be different without Chronic Pain? Halia is focused on making the answer to that question a reality.
*Names and likenesses are changed to protect patient privacy.
When I was young, I never imagined I would be in so much constant pain at this age. I don’t even remember what it was like to not be in pain constantly.
Pain and Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.8% to 1.0% of the population, with higher prevalence among first-degree relatives.7 Characterized by joint inflammation, synovial hyperplasia, and systemic manifestations, RA is a leading cause of disability.8 Despite advances in disease-modifying antirheumatic drugs (DMARDs), 20% to 30% of patients fail to achieve sustained low disease activity or remission with current therapies.9 This underscores the critical need for novel treatment options.
Obesity
Almost half of US adults are obese or severely obese. Lack of physical activity, unhealthy eating behavior, and, in some cases, genetics contribute to obesity. Halia is developing investigational treatments to combat obesity.
Pain and Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an autoimmune condition where the immune system—normally the body's defender against infection and disease—attacks its own tissues. This results in pain, swelling, stiffness, and loss of joint function. Halia is developing an investigational treatment for both RA and post-surgical pain.
Alzheimer's Disease
Alzheimer’s disease involves parts of the brain that control memory, language, problem-solving, and other thinking abilities. It can seriously affect a person’s ability to carry out daily activities. Halia is developing a potentially relevant pathway and investigational treatment for Alzheimer’s.
Parkinson's Disease
Parkinson’s disease is a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves. Tremors, stiffness, or slowing of movement are typical symptoms. Halia is developing a potential brain-penetrant compound to treat the disease.