Parkinson’s Disease
HT-6283: Investigating Neuroinflammation in Parkinson’s Disease Targeting Inflammation in Neurodegenerative Diseases
Alan’s* Day
SAMPLE DAILY EXPERIENCES WITH PARKINSON’S DISEASE
Living with Parkinson’s disease presents daily challenges to Alan that are physically and emotionally demanding. His tremors, stiffness, and slowed movements often make simple tasks like dressing, eating, or writing challenging. Even walking can be hazardous due to his balance issues, increasing the risk of falls. The unpredictability of symptoms adds to Alan’s stress, never knowing when his mobility will suddenly decline.
Cognitive changes, such as memory loss or difficulty concentrating, make everyday activities like planning or decision-making overwhelming for Alan. Additionally, fatigue leaves him exhausted by even minimal exertion.


Each day, Alan tries to cope with anxiety, depression, and frustration stemming from the loss of independence and his burden on loved ones. Social interactions are strained as Alan feels self-conscious and isolated. Alan struggles daily to maintain his quality of life amidst his constant challenges.
What if Alan’s courage and positive hopes could be realized and he could live a life free of the impact of Parkinson’s Disease?
Halia is focused on making the answer to that question a reality.
*Names and likenesses are changed to protect patient privacy.

I wonder when people see me struggling with tremors and stiffness if they know my mind is still sharp. I love to just sit and talk.

Parkinson’s Disease
Parkinson’s disease (PD) is characterized by the accumulation of misfolded α-synuclein and the loss of dopaminergic neurons, resulting in movement disorders.12 Recent research has highlighted the crucial role of the NLRP3 inflammasome in the neuroinflammatory processes that exacerbate PD.13 When activated, the NLRP3 inflammasome, a cytosolic multiprotein complex, triggers the production of pro-inflammatory cytokines such as IL-1β and IL-18. These cytokines play a critical role in the inflammatory response within the central nervous system. In PD, the buildup of misfolded α-synuclein activates the NLRP3 inflammasome in microglia and astrocytes.14
Obesity
Almost half of US adults are obese or severely obese. Lack of physical activity, unhealthy eating behavior, and, in some cases, genetics contribute to obesity. Halia is developing investigational treatments to combat obesity.
Pain and Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an autoimmune condition where the immune system—normally the body's defender against infection and disease—attacks its own tissues. This results in pain, swelling, stiffness, and loss of joint function. Halia is developing an investigational treatment for both RA and post-surgical pain.
Alzheimer's Disease
Alzheimer’s disease involves parts of the brain that control memory, language, problem-solving, and other thinking abilities. It can seriously affect a person’s ability to carry out daily activities. Halia is developing a potentially relevant pathway and investigational treatment for Alzheimer’s.
Parkinson's Disease
Parkinson’s disease is a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves. Tremors, stiffness, or slowing of movement are typical symptoms. Halia is developing a potential brain-penetrant compound to treat the disease.